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NMN 101; All You Need to Know

Rewind 20 years – when a group of scientists discovered that yeast contains the SIRT1 gene, also known as sirtuins, which are known to control the aging process. Upon further research, these enzymes were found to be naturally occurring in the human body, where their primary function is regulating cellular stress response and repairing DNA. Studies progressed, finding that the activation of sirtuins require NAD+, which NMN is a precursor to. Presently, this information has taken the anti-aging industry by storm. If this is the first you are hearing about NMN, read on. This article will breakdown exactly what NMN is and does.

NMN, or Nicotinamide Mononucleotide, and its uses is a complex subject, which is why we are here to break it down.

First… NAD+

To fully understand NMN, we must first understand NAD+. NAD+, or nicotinamide adenine dinucleotide, is a molecule that naturally occurs in all life forms. NAD+ is a coenzyme that converts nutrient energy so that it can be used by cells, such as sirtuins,. As we mentioned, sirtuins have a pretty impressive job; to regulate cellular stress response and repair DNA. As we age, our NAD+ levels decline, resulting in decreased sirtuin activity. With decreased sirtuin activity, we begin to show signs of aging and become increasingly susceptible to age-related disease.

The bottom line; The levels of NAD+ in someone's cells determines the speed of their aging process.

So What Role Does NMN Play?

NMN, or nicotinamide mononucleotide, like NAD+, is a molecule naturally occurring in all life forms. It is a vitamin B3 (niacin) derivative, which can also be found in various vegetables, fruits, and meat in small amounts. In its naturally produced state, NMN is a precursor to NAD+, meaning it becomes NAD+ through a series of chemical transformations.

While the main molecule that is effective in anti-ageing is NAD+, research showed that administering NAD+ supplements is not effective because the NAD+ molecules are unable to pass through cell membranes on their own, prompting the need for NAD+ precursors like NMN.

When ingested, NAD+ and NMN do not have the same capacity – NAD+ cannot travel through the blood-brain route, ultimately keeping the molecule from penetrating cells. Conversely, NMN is able to travel the blood-brain route and enter cells, proving it a successful way to increase NAD+ levels.

What are the Benefits of Supplementing NMN?

By supplementing NMN, it’s possible to increase NAD+ levels, offering biological protection from cell deterioration. NMN is believed to have the potential to slow-down or even halt the aging process. Specific anti-aging benefits include anti-inflammatory effects, improved brain function, and combat diseases such as, cardiovascular disease, neurodegenerative diseases, and cancer. Recent human trials have recorded benefits like increased energy and muscle recovery. Additional believed benefits include improved hair and skin health, by boosting the functionality of the mitochondria.

How Do We Know NMN Works?

Upon many years of research, a Harvard geneticist, David Sinclair, was among the first scientists NMN and NAD+ relationship, as well as the benefits of supplementing NMN. The foundation of NMN research has been performed as animal trials, all with promising results. More recently, human trials have begun to take place and have resulted in equally promising results. For details on these trials, visit our recent blog posts here.

The NMN 101

As NMN continues to be researched, the results are encouraging and scientists are hopeful. The coenzyme is currently deemed the ‘the fountain of youth for the masses’ in the anti-aging market, and we are excited to follow the evidence as it emerges.

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